蛋白质的变性在医学上有什么意义
蛋白质的变性在医学上有什么意义
推荐回答(4个)
蛋白质变性是指蛋白质在某些物理和化学因素作用下其特定的空间构象被改变,从而导致其理化性质的改变和生物活性的丧失。强酸、强碱、加热(高温——煮鸡蛋)、紫外线(紫外线消毒)等都可以导致蛋白质变性!以上这些在工作和生活中经常可以遇到!蛋白质变性有许多实际应用,如乙醇消毒灭菌、煮沸、临床紫外线照射、临床实验室加热凝固反应检测尿蛋白、日常生活中烹饪和食用蛋白质消化等,但另一方面,鸡蛋在制备保存的蛋白质制剂中(如酶、疫苗、免疫血清等)。白质变性以防止失活。蛋白质变性是指蛋白质在某些物理和化学因素作用下其特定的空间构象被改变,从而导致其理化性质的改变和生物活性的丧失,这种现象称为蛋白质变性。
蛋白质变性的条件有很多种,变性条件按物理因素来说分别有干燥、加热、高压、振荡或搅拌、紫外线、,射线、超声,即只要提供能量,打破其原有结构皆可。化学因素有加强酸、强碱,即改变其,,值,调节蛋白质三级结构中氢键、离子间的相互作用;尿素,本身具有疏水性,可使蛋白质内疏水性结构外翻,导致其沉淀变性;重金属盐、生物碱试剂(三氯乙酸、乙醇等)。
蛋白质变性后,会丧失生物活性,溶解度降低,最重要的是易被水解,即对水解酶的抵抗力减弱。例如食用食物时应使蛋白质变性(加热、腌制、风干),才易消化。
蛋白质变性亦可在医学上得到充分的利用: ,(杀菌、消毒:酒精、碘酒用于肌内注射、静脉注射前的杀菌消毒原理:酒精可使蛋白质变性,碘则作用在苯环上,含有苯环的氨基酸会被碘取代,表面看上去皮肤会变黄。
注意:使用的酒精浓度为多少,为什么不用,,,,的酒精,因为,我们的目的是杀死整个细菌,,,,,的酒精使蛋白质外层全部迅速变性,剩余酒精难以进入细菌内部,仍有活性,就像浓硫酸使铁钝化,反应无法继续进行。而,,,的酒精既可使蛋白质外层变性,又可渗透入细菌内部,内部蛋白也变性了,细菌彻底被杀死。,(排毒:用于重金属盐中毒的急救原理:如体温计不慎在嘴中破碎,可大量食用蛋清、豆浆、牛奶等蛋白质含量较高的食物,再洗胃,使离子结合食物蛋白,不至于进入体内而危害体内的蛋白。
再如氰化物中毒时的弃卒保车之法。急性氰化物中毒的病情发展迅速,故急性中毒的抢救应分秒必争,强调就地应用解毒剂。我们知道,血红蛋白中的血红素中含有二价铁,负责运载氧气;而细胞中有一类似血红素的铁可在二价铁和三价铁间变价,在呼吸作用时利用氧气通过氧化还原反应产生能量。而氰根可与三价铁牢固结合,氧化还原无法继续,细胞便无法获取能量,导致生命危险。食用可导致食物中毒的亚硝酸盐则具有强氧化性,将血液中血红蛋白的二价铁变为三价铁,使其运载氧气能力下降。人体内的血红蛋白多于细胞中氧化还原的酶,故在氰化物中毒后,无硫代硫酸钠的情况下,可食用适量亚硝酸盐!
将细菌、病毒加温,加酸、加重金属汞,因蛋白质变性达到灭活的效果。
当病人因皮肤破裂引起出血时,用冰块将出血的部位冷冻起来,使表面的血凝固,阻止内部的血液流出。
降低病菌的活性,防止感染,也是应用了蛋白质的变性.
生物活性丧失导致相应疾病的发生。
蛋白质的生物活性是指蛋白质所具有的酶、激素、毒素、抗原与抗体、血红蛋白的载氧能力等生物学功能。
生物活性丧失是蛋白质变性的主要特征。
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