what do you think of How do you think of 有什么区别吗

how do you think of的用法是错的， How是问方式方法 think 的问题是问“想”的内容（宾语），所以不能用how,必须用what：
What are you thinking of?  你在想什么?
What do you think of it?  你认为这事怎么样？
如果“你是怎样想的？” 用how，是中式英语。就连“你怎么会这么想的？”都不用how:  Why do you think so?

拓展资料：

how是一个英语单词，可做副词和感叹词用，意思是如何;怎么;怎样;多么;怎么样等。在英语中通常用作副词，是特殊疑问句中本领最大的疑问词。关于how的用法：

一、how单独用作疑问词.

1. 问身体健康等情况：How are your parents?你父母身体好吗?How are things in your father's factory?你爸爸厂里的情况怎么样?

2. 问天气状况：How is the weather today?今天天气怎么样?

3. 询问方式：How does your mother go to work every day?你妈妈每天怎么去上班?How can I carry the box upstairs?我怎样才能把这箱子搬到楼上呢?

4. 询问程度：How do you like this book?你觉得这本书怎么样?

二、与其它形容词或副词搭配使用

1. How old问年龄、年代：How old is your friend?你朋友多大了?How old is the bridge?这座桥有多少年代了?

2. How many问可数名词数量.常将可数名词复数紧随其后.如：How many pictures are there on the wall?墙上有多少幅画?How many glasses of milk would you like?你们想要几杯牛奶?

3. How much询问不可数名词的数量、物品的价格：How much money is there in the purse?钱包里有多少钱?How much are the apples at the moment?目前苹果什么价钱?

4. How long提问物体的长度、时间的长短：How long is the Changjia River?长江有多长?How long does it take you to do your homework every day?你每天花多长时间做作业?

5. How soon 对 "in+一段时间 "提问,表示"多久之后"：How soon will you be back?你多久后回来?

6. How often对表示频率的副词或短语提问：How often does Mrs.Green go shopping?格林夫人多久去购一次物?

7. How about用来征求对方意见：Your father is a worker,how about your mother?你父亲是工人,你母亲呢?How about playing games after school this afternoon?下午放学后做游戏怎么样?

一个是问你在思考什么，是内容
一个是问你如何思考，是方式

没太大区别啦，不过一般“What do you thing of ”和“How do you like”用得多一点

问别人对某事物有何看法我们常用以下两个句型：
1 What do you think of ...?
2 How do you like ...?
但是很多人都会混淆，误用了How do you think of ...?

what do you think of?与 How do you think of ？表达的意思差不多。但也有区别。
what do you think of？ 你认为是什么？
How do you think of ？ 你认为怎么样？